A new one-pot solvent-free synthesis of pyridinyl tosylates via diazotization of aminopyridines

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• 作者：Alexey N. Tretyakov ; Elena A. Krasnokutskaya ; Dmitry A. Gorlushko ; Vladimir D. Ogorodnikov ; Victor D. Filimonov
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：5 January 2011
• 年：2011
• 卷：52
• 期：1
• 页码：85-87
• 全文大小：334 K

文摘

A new, convenient, one-pot method for the synthesis of pyridinyl tosylates is developed. The procedure involves sequential diazotization/tosylation of aminopyridines with sodium nitrite and p-toluenesulfonic acid under solvent-free conditions in a water paste at room temperature.