Cytotoxic activity of sesquiterpene lactones from Inula britannica on human cancer cell lines

详细信息    查看全文

• 作者：Justin T. Fischedick^a ; ^b ; ^{justin.fischedick@wsu.edu} ; Milica Pesic^c ; Ana Podolski-Renic^c ; Jasna Bankovic^c ; Ric C.H. de Vos^d ; ^e ; Marija Peri?^f ; Sla?ana Todorovi?^g ; Nikola Tanic^c
• 关键词：(P-gp) ; P-glycoprotein ; (MDR) ; multi-drug resistance ; (MRP1) ; multi-drug resistance associated protein 1
• 刊名：Phytochemistry Letters
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：6
• 期：2
• 页码：246-252
• 全文大小：588 K

文摘

Five new sesquiterpene lactones (1-5) were isolated from Inula britannica collected in the wild from Serbia along with five known compounds (6-10). Sesquiterpene lactones were isolated using centrifugal partition chromatography followed by combination of flash chromatography and semi-preparative HPLC. Isolated compounds were screened for cytotoxic activity on four different human cancer cell lines and their multi-drug resistant counterparts, as well as on normal human keratinocytes. Sesquiterpene lactones showed similar cytotoxic activity toward drug sensitive and drug resistant cancer cell lines.