Low dose evaluation of the antiandrogen flutamide following a Mode of Action approach

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Low dose evaluation of the antiandrogen flutamide following a Mode of Action approach

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作者：A. Sarrabay^a ; ^b ; ^c ; C. Hilmi^c ; H. Tinwell^c ; F. Schorsch^c ; M. Pallardy^a ; ^b ; R. Bars^c ; D. Rouquié ; ^c ; ^{david.rouquie@bayer.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Flutamide ; Low-dose ; Leydig cell hyperplasia ; Mode of action ; Threshold
刊名：Toxicology and Applied Pharmacology
出版年：2015
出版时间：15 December 2015
年：2015
卷：289
期：3
页码：515-524
全文大小：1008 K

文摘

•: Dose–response characterization of endocrine mediated toxicity is an on-going debate.
•: A wide range of dose levels of flutamide was evaluated on young adult male rats.
•: Flutamide induces threshold effects using on standard and molecular tools.

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