刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:February 2017
年:2017
卷:1863
期:2
页码:518-528
全文大小:1030 K
卷排序:1863
文摘
Epigenetic state plays an important role in disease manifestation. DNA methylation, histone modification, nucleosomal positioning and miRNA, mediate major epigenetic regulation. Environmental factors are also responsible for associate alteration of the epigenetic state. Targeting the epigenetic machinery is a newer approach to change the altered epigenetic state.
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