CD5⁻ diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case

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• 作者：Marco Lucioni MD ; PhD^a ; ^{m.lucioni@smatteo.pv.it"" rel=""nofollow} ; Francesca Novara MSc^b ; Roberta Riboni PhD^a ; Giacomo Fiandrino MD^a ; Marta Nicola MD^a ; Sandra Kindl MD^c ; Emanuela Boveri MD^a ; Vassili Jemos MD^d ; Luca Arcaini MD^e ; Orsetta Zuffardi PhD^b ; Marco Paulli MD ; PhD^a
• 关键词：Diffuse large B-cell lymphoma ; Cyclin D1 ; Mantle cell lymphoma ; Array comparative genomic hybridization
• 刊名：Human Pathology
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：42
• 期：8
• 页码：1204-1208
• 全文大小：882 K

文摘

Summary

Increased expression of cyclin D1 is notoriously associated with mantle cell lymphoma because of translocation t(11;14)(q13;q32) or variants involving the cyclin D1 gene. We present an unusual case of CD5-negative diffuse large B-cell lymphoma expressing cyclin D1 in the absence of translocation by fluorescence in situ hybridization analysis. Using array-comparative genomic hybridization, we found a complex karyotype without the characteristic chromosomal aberrations accompanying cyclin D1 translocation in mantle cell lymphoma; instead, there was monoallelic deletion of AKT interacting protein and glycogen synthase kinase-3 β genes, both involved in the AKT/glycogen synthase kinase-3 β cascade-controlling nuclear levels of cyclin D1. These findings suggest that posttranslational events regulating cyclin D1 activity may take place also in a subset of diffuse large B-cell lymphomas and contribute to lymphomagenesis. As a consequence, the sole cyclin D1 positivity by immunohistochemistry may not be enough to distinguish pleomorphic/blastoid mantle cell lymphoma from diffuse large B-cell lymphoma. Search for t(11;14) with fluorescence in situ hybridization probes should always be performed in doubtful cases.