Preliminary data on immunogenicity, safety and tolerability of trivalent inactivated influenza vaccine in children with inborn errors of metabolism at risk of decompensation

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• 作者：Susanna Esposito ; Filippo Salvini ; Francesca Menni ; Alessia Scala ; Elisabetta Salvatici ; Francesca Manzoni ; Enrica Riva ; Marcello Giovannini ; Nicola Principi
• 关键词：Children ; Influenza virus ; Influenza vaccine ; Metabolic disease ; Trivalent influenza vaccine
• 刊名：Vaccine
• 出版年：25 October, 2013
• 年：2013
• 卷：31
• 期：45
• 页码：5149-5151
• 全文大小：297 K

文摘

In order to evaluate the immunogenicity, safety and tolerability of influenza vaccination in children with inborn errors of metabolism (IEMs), we enrolled 20 patients with IEMs at risk of decompensation (14 males; mean age 卤 SD, 8.5 卤 3.9 years) and 20 healthy age- and gender-matched controls. Four weeks after vaccination, seroconversion rates were 75-85% and seroprotection rates 85-95%, with high geometric mean titers (GMTs) of all three influenza antigen strains in both groups. Three months after vaccination, most of the subjects remained seroconverted with high seroprotection rates and high GMTs for all the three influenza strains. Safety and tolerability were also very good, with no differences between the groups.