Complementary pharmacological and toxicological characterization data on the pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl) acetamide

详细信息    查看全文

• 作者：Myrna Dé ; ciga-Campos^a ; ^{myrnadeciga@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{mdeciga@ipn.mx" class="auth_mail" title="E-mail the corresponding author} ; Gabriel Navarrete-Vá ; zquez^b ; Francisco Javier Ló ; pez-Muñ ; oz^c ; Tadeusz Librowski^d ; Amanda Sá ; nchez-Recillas^e ; Victor Yañ ; ez-Pé ; rez^e ; Rolffy Ortiz-Andrade^e
• 关键词：LIA ; N-(2 ; 6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide ; MNPCE ; micronucleated polychromatic erythrocytes ; PCE ; polychromatic erythrocytes ; NCE ; normochromatic erythrocytes ; IC50 ; half maximal inhibitory concentration ; LD50 ; half lethal dose ; LC50 ; half lethal concentration ; CYP-P450 ; cytochrome P-450 ; HR ; heart rate ; SBP ; systolic blood pressure ; DBP ; diastolic blood pressure
• 刊名：Data in Brief
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：8
• 期：Complete
• 页码：1007-1012
• 全文大小：295 K

文摘

This text presents complementary data corresponding to pharmacological and toxicological characterization of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled “Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analog of lidocaine” Déciga-Campos M., Navarrete-Vázquez G., López-Muñoz F.J., Librowski T., Sánchez-Recillas A., Yañez-Pérez V., Ortiz-Andrade R. (2016) [1]. Toxicity was predicted through the ACD/ToxSuite software and evaluated in vivo using brine shrimp larvae (Artemia salina L.) and mice. Also, we used the micronucleus assay to determine genotoxicity. We used the platform admetSAR to predict absorption properties of LIA and lidocaine.