Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks

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• 作者：Ildem Akerman¹ ; ² ; ³ ; Zhidong Tu⁴ ; Anthony Beucher¹ ; Delphine M.Y. Rolando¹ ; Claire Sauty-Colace⁵ ; Marion Benazra⁵ ; Nikolina Nakic¹ ; Jialiang Yang⁴ ; Huan Wang⁴ ; Lorenzo Pasquali³ ; ⁶ ; Ignasi Moran¹ ; Javier Garcia-Hurtado² ; ³ ; Natalia Castro² ; ³ ; Roser Gonzalez-Franco¹ ; Andrew F. Stewart⁷ ; Caroline Bonner⁸ ; Lorenzo Piemonti⁹ ; Thierry Berney¹⁰ ; Leif Groop¹¹ ; Julie Kerr-Conte⁸ ; Francois Pattou⁸ ; Carmen Argmann⁴ ; Eric Schadt⁴ ; Philippe Ravassard⁵ ; Jorge Ferrer¹ ; ² ; ³ ; ¹² ; ^{jferrerm@imperial.ac.uk}
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：400-411
• 全文大小：3532 K
• 卷排序：25

文摘

A loss-of-function screen reveals functional β cell lncRNAs Cell-specific lncRNAs and transcription factors regulate common gene networks The lncRNA PLUTO influences interactions between an enhancer cluster and PDX1 PLUTO and PDX1 are deregulated in type 2 diabetes and impaired glucose tolerance