Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients

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• 作者：Angela Deutschlä ; nder^a ; Christian la Fougè ; re^b ; Kai Boetzel^a ; Nathalie L. Albert^c ; Franz-Josef Gildehaus^c ; Peter Bartenstein^c ; Guoming Xiong^c ; Paul Cumming^d ; ^e ; ^{paul.cumming@qut.edu.au}
• 关键词：Parkinson's disease ; Pet ; Fallypride ; Pramipexole ; Agonist ; Dopamine receptors ; Occupancy
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：41-46
• 全文大小：539 K
• 卷排序：12

文摘

Fallypride PET recordings in nine PD patients, scanned on- and off medication with pramipexole No occupancy in the striatum, despite improved motor symptoms Substantial occupancy in substantia nigra, thalamus and globus pallidus