Epigenetic Classification of Human Mesenchymal Stromal Cells

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Epigenetic Classification of Human Mesenchymal Stromal Cells

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作者：Danilo Candido de Almeida¹ ; ² ; ³ ; Marcelo R.P. Ferreira⁴ ; ⁵ ; Julia Franzen¹ ; ² ; Carola I. Weidner¹ ; ² ; Joana Frobel¹ ; ² ; Martin Zenke² ; ⁶ ; Ivan G. Costa⁴ ; Wolfgang Wagner¹ ; ² ; ^{wwagner@ukaachen.de" class="auth_mail" title="E-mail the corresponding author}
关键词：epigenetic score ; mesenchymal stromal cell ; mesenchymal stem cell ; fibroblast ; bone marrow ; adipose tissue ; DNA methylation
刊名：Stem Cell Reports
出版年：2016
出版时间：9 February 2016
年：2016
卷：6
期：2
页码：168-175
全文大小：2549 K

文摘

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Mesenchymal stromal cells and fibroblasts have different DNA methylation patterns

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A two-CpG signature can distinguish between MSCs and fibroblasts

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Another two-CpG signature can discern MSCs from bone marrow and adipose tissue

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Subclones of MSCs are correctly classified by these epigenetic scores

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