Dietary nitrate markedly improves voluntary running in mice

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• 作者：Niklas Ivarsson ; ^{Niklas.ivarsson@ki.se} ; Tomas A. Schiffer ; André ; s Herná ; ndez ; Johanna T Lanner ; Eddie Weitzberg ; Jon O. Lundberg ; Hå ; kan Westerblad
• 关键词：[Ca2&#xA0 ; +]i ; free cytosolic [Ca2&#xA0 ; +] ; CSQ1 ; calsequestrin 1 ; COX1 ; cytochrome c oxidase subunit 1 ; CS ; citrate synthase ; Ctrl ; control ; DHPR ; dihydropyridine receptor ; EDL ; extensor digitorum longus ; Nit ; nitrate ; P/O ; oxidative phosphorylation efficiency ; RCR ; respiratory control ratio ; RyR1 ; ryanodine receptor 1 ; Run ; runner ; Sed ; sedentary ; SR ; sarcoplasmic reticulum
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：55-61
• 全文大小：634 K
• 卷排序：168

文摘

Voluntary in-cage wheel running is increased in mice supplemented with nitrate. When dietary nitrate is removed, running decreases to the control level. Dietary nitrate improves submaximal muscle force. Dietary nitrate does not enhance endurance or mitochondrial function in sedentary animals. Mice given dietary nitrate get a higher oxidative capacity and become more fatigue resistant because they run more.