Comparison of Cyclophosphamide Combined with Total Body Irradiation, Oral Busulfan, or Intravenous Busulfan for Allogeneic Hematopoietic Cell Transplantation in Adults with Acute Lymphoblastic Leukemia

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Comparison of Cyclophosphamide Combined with Total Body Irradiation, Oral Busulfan, or Intravenous Busulfan for Allogeneic Hematopoietic Cell Transplantation in Adults with Acute Lymphoblastic Leukemia

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作者：Kenjiro Mitsuhashi¹ ; ^{kmitsuhashi@twmu.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Shinichi Kako² ; Akio Shigematsu³ ; Yoshiko Atsuta⁴ ; ⁵ ; Noriko Doki⁶ ; Takahiro Fukuda⁷ ; Heiwa Kanamori⁸ ; Makoto Onizuka⁹ ; Satoshi Takahashi¹⁰ ; Yukiyasu Ozawa¹¹ ; Mineo Kurokawa¹² ; Yoshiko Inoue¹³ ; Tokiko Nagamura-Inoue¹⁴ ; Yasuo Morishima¹⁵ ; Shuichi Mizuta¹⁶ ; Junji Tanaka¹ ; on behalf of the Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society for Hematopoietic Cell Transplantation
关键词：Acute lymphoblastic leukemia ; Allogeneic hematopoietic cell transplantation ; Total body irradiation ; Busulfan
刊名：Biology of Blood and Marrow Transplantation
出版年：2016
出版时间：December 2016
年：2016
卷：22
期：12
页码：2194-2200
全文大小：377 K

文摘

•: This retrospective analysis compared total body irradiation (TBI)/cyclophosphamide (CY), oral busulfan (BU)/CY, and i.v. BU/CY.
•: The data were provided from the Japanese nationwide database.
•: Oral BU/CY, but not i.v. BU/CY, was associated with shorter overall survival compared with TBI/CY.
•: i.v. BU/CY might be a possible alternative conditioning regimen for adults undergoing allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia.