CD40—CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)

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• 作者：Narayanaswamy Ramesh ; Tomohiro Morio ; Ramsay Fuleihan ; Margitta Worm ; Anthony Horner ; Erdyni Tsitsikov ; Emanuela Castigli ; Raif S. Geha
• 刊名：Clinical Immunology and Immunopathology
• 出版年：1995
• 出版时间：September 1995
• 年：1995
• 卷：76
• 期：3, Part 2
• 页码：S208-S213
• 全文大小：674 K

文摘

Interactions between the B cell surface antigen CD40 and its ligand (CD40L) expressed on activated T cells play a critical role in isotype switching. This is illustrated by failure of isotype switching in patients with X-linked hyperIgM syndrome in whom the CD40L gene is mutated and by failure of isotype switching of CD40-deficient mice in response to T-cell-dependent antigens. We review these findings and discuss the signaling mechanisms of CD40 and the developmental control and transcriptional regulation of CD40L expression.