A comparison of single breath and re-breathe diffusing capacity in emphysema patients and controls

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• 作者：Jeremy A. Weingarten ; David J. Lederer ; Erkan Ozturk ; Fulvia M. Milite ; Anne M. Mooney ; Byron M. Thomashow ; Robert C. Basner
• 关键词：Pulmonary function testing ; Copd
• 刊名：Respiratory Physiology & Neurobiology
• 出版年：2012
• 出版时间：31 July, 2012
• 年：2012
• 卷：183
• 期：1
• 页码：15-19
• 全文大小：289 K

文摘

In emphysema patients, gas dilutional alveolar volume is underestimated by a 10 s single breath maneuver at total lung capacity (TLC) compared with re-breathing at functional residual capacity (FRC); corresponding underestimation of single breath diffusing capacity (DLCO) in emphysema has not been demonstrated. The purpose of this study was to quantify the degree to which re-breathe DLCO at FRC (DLCO_RB) differs from single breath DLCO at TLC (DLCO_SB) in emphysema.

In 37 consecutively recruited patients with moderate to severe emphysema (FEV₁/FVC 40 %  ¡À 10 % predicted), DLCO_RB as % predicted of 91 controls without cardiopulmonary disease was 79 %  ¡À 24 % , significantly greater than % predicted DLCO_SB (44 %  ¡À 19 % ; p < 0.0001). DLCO_RB/DLCO_SB was inversely proportional to FEV₁ % predicted (R = ?0.47, p = 0.004), and FEV₁/FVC (R = ?0.54, p < 0.001).

These data indicate that a 10 s single breath DLCO maneuver progressively under-represents re-breathe lung diffusing capacity in emphysema as airflow obstruction increases.