Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development

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Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development

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作者：Sadanori Watanabe¹ ; ^{sadanori.watanabe@bio.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Go Shioi² ; Yasuhide Furuta² ; ³ ; Gohta Goshima¹ ; ^{goshima@bio.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}
关键词：augmin ; γ-tubulin complex ; early mouse development ; MTOC clustering ; spindle
刊名：Cell Reports
出版年：2016
出版时间：5 April 2016
年：2016
卷：15
期：1
页码：54-60
全文大小：2666 K

文摘

•: An augmin knockout (KO) mouse is used to examine microtubule nucleation
•: Augmin is essential for embryonic cell division during mouse development
•: Live imaging of synchronized embryos reveals augmin-dependent clustering of MTOCs
•: Intra-spindle MT assembly, but not augmin itself, is required for MTOC clustering

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