Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

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Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

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作者：Adam P. Kardon¹ ; ² ; ⁹ ; Erika Polgá ; r³ ; ⁹ ; Junichi Hachisuka¹ ; ² ; Lindsey M. Snyder¹ ; ² ; Darren Cameron³ ; Sinead Savage³ ; Xiaoyun Cai¹ ; ² ; Sergei Karnup¹ ; ² ; Christopher R. Fan¹ ; Gregory M. Hemenway¹ ; Carcha S. Bernard¹ ; Erica S. Schwartz² ; ⁴ ; Hiroshi Nagase⁵ ; Christoph Schwarzer⁶ ; Masahiko Watanabe⁷ ; Takahiro Furuta⁸ ; Takeshi Kaneko⁸ ; H. Richard Koerber¹ ; ² ; Andrew J. Todd³ ; ^{andrew.todd@glasgow.ac.uk" class="auth_mail} ; Sarah E. Ross¹ ; ² ; ⁴ ; ^{saross@pitt.edu" class="auth_mail}
刊名：Neuron
出版年：7 May 2014
年：2014
卷：82
期：3
页码：573-586
全文大小：3660 K

文摘

•: Spinal B5-I interneurons function to inhibit itch
•: B5-I neurons release the kappa opioid dynorphin
•: Kappa opioid signaling bidirectionally modulates itch within the spinal cord
•: Spinal B5-I interneurons mediate the inhibition of itch by menthol

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