Novel oral administrated paclitaxel micelles with enhanced bioavailability and antitumor efficacy for resistant breast cancer

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• 作者：Ting Zhang^a ; ^b ; ¹ ; Jingwen Luo^a ; ¹ ; Yao Fu^a ; Hanmei Li^a ; Rui Ding^c ; ^{dingrui1001@aliyun.com} ; Tao Gong^a ; ^{gongtaoy@126.com} ; Zhirong Zhang^a
• 关键词：Paclitaxel ; Multidrug resistance ; P-glycoprotein inhibitor ; Micelles ; Oral bioavailability ; Permeability
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：89-97
• 全文大小：2538 K
• 卷排序：150

文摘

A facile one-step self-assembled method of making micelles. The micelles were formulated without using toxic organic solvent. Improved oral bioavailability and effective anticancer effects. Reversing the P-gp mediated multi-drug resistance both in vitro and in vivo.