Human semen as an early, sensitive biomarker of highly polluted living environment in healthy men: A pilot biomonitoring study on trace elements in blood and semen and their relationship with sperm quality and RedOx status

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• 作者：Paolo Bergamo^a ; ^{paolo.bergamo@isa.cnr.it} ; Maria Grazia Volpe^a ; ^{mgvolpe@isa.cnr.it} ; Stefano Lorenzetti^b ; ^{stefano.lorenzetti@iss.it} ; Alberto Mantovani^b ; ^{alberto.mantovani@iss.it} ; Tiziana Notari^c ; ^{tiziananotari7@gmail.com} ; Ennio Cocca^d ; ^{ennio.cocca@ibbr.cnr.it} ; Stefano Cerullo^a ; ^{dyer88@hotmail.it} ; Michele Di Stasio^a ; ^{michele.distasio@isa.cnr.it} ; Pellegrino Cerino^e ; ^{strategia@izsmportici.it} ; Luigi Montano^f ; ^{l.montano@aslsalerno.it}
• 关键词：DFI ; DNA fragmentation Index ; G6PD ; glucose 6-phosphate dehydrogenase ; GCL ; γ-Glutamate Cysteine Ligase ; GPX ; glutathione peroxidase ; GSH ; reduced glutathione ; GSR ; Glutathione-S reductase ; GSSG ; oxidized glutathione ; GST ; glutathione S-transferase ; HIGH ; high exposure ; LOW ; low exposure ; Nrf2 ; nuclear factor erythroid-2-related factor 2 ; PC ; protein bound carbonyls ; PCA ; Principal Component Analysis ; ROS ; reactive oxygen species ; SH ; total sulfhydryl groups ; TAC ; total antioxidant capacity
• 刊名：Reproductive Toxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：66
• 期：Complete
• 页码：1-9
• 全文大小：1390 K
• 卷排序：66

文摘

Trace elements in semen and blood discriminate people living in polluted areas. Seminal plasma is more sensitive than blood to redox status alteration. Lower sperm quality and antioxidant defenses associated to highly polluted area. In healthy males, semen is proposed as early biomarkers of environmental pollution.