On the optimal design of gas-expanded liquids based on process performance
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A generic approach is developed to assess and design gas-expanded liquids.

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Proposed approach is applied to Diels–Alder reaction, using three organic co-solvents.

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Effect of co-solvent choice and concentration on process performance is investigated.

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Mildly expanded liquids are sometimes beneficial; compression costs dominate economics.

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Large reduction in organic solvent can be achieved at higher gas concentrations.

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