Ventral Striatum Functional Connectivity during Rewards and Losses and Symptomatology in Depressed Patients

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• 作者：Karina Quevedo^a ; ^{queve001@umn.edu} ; Rowena Ng^b ; ^{rowenang@umn.edu} ; Hannah Scott^a ; ¹ ; ^{hlscott@umn.edu} ; Srivastava Kodavaganti^c ; ² ; ^{srk37@pitt.edu} ; Garry Smyda^c ; ³ ; ^{gwsmyda@gmail.com} ; Vaibhav Diwadkar^d ; ^{vdiwadka@med.wayne.edu} ; Mary Phillips^e ; ^{phillipsml@upmc.edu}
• 关键词：Imaging ; Imaging ; Depression ; Adults ; Functional connectivity ; Ventral striatum ; Reward circuitry ; Corticostriatal network ; Anhedonia ; Suicidality ; Depressed mood
• 刊名：Biological Psychology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：62-73
• 全文大小：1750 K
• 卷排序：123

文摘

We examined the striatal network, which encodes natural rewards, in depressed and healthy adults. Depressed adults show high striatal connectivity with neocortical areas during losses versus rewards. Suicidality, anhedonia, and depressive mood are associated with higher VS connectivity to the Prefrontal Cortex.