Acoustic cavitation induced generation of stabilizer-free, extremely stable reduced graphene oxide nanodispersion for efficient delivery of paclitaxel in cancer cells

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• 作者：Renu Geetha Bai<sup>asup> ; Kasturi Muthoosamy<sup>asup> ; Fiona Natalia Shipton<sup>bsup> ; Sivakumar Manickam<sup>asup><sup> ; sup><sup>Sivakumar.Manickam@nottingham.edu.mysup>
• 关键词：Reduced graphene oxide ; Aqueous dispersion ; Ultrasound ; Shockwave ; Cavitation ; Paclitaxel ; Nanodispersion
• 刊名：Ultrasonics Sonochemistry
• 出版年：2017
• 出版时间：May 2017
• 年：2017
• 卷：36
• 期：Complete
• 页码：129-138
• 全文大小：2111 K
• 卷排序：36

文摘

Ultrasound induces stabilizer-free, aqueous RGO nanodispersion (>2 years-stable). It is simple, straightforward, eco-friendly and scalable approach. No harsh/toxic chemicals utilized in the development of RGO dispersion. Ptx, an anticancer drug utilized to check the loading capacity of RGO dispersion. In vitro analysis of RGO-Ptx exhibited dose-dependent toxicity to cancer cells.