Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways

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Genistein attenuates D-GalN induced liver fibrosis/chronic liver damage in rats by blocking the TGF-β/Smad signaling pathways

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作者：Ajaz Ahmad Ganai ; Mohammad Husain ; ^{biotechpharma2020@gmail.com}
关键词：Cirrhosis ; Steatohepatitis ; Oxidative stress ; Apoptosis
刊名：Chemico-Biological Interactions
出版年：2017
出版时间：5 January 2017
年：2017
卷：261
期：Complete
页码：80-85
全文大小：1278 K
卷排序：261

文摘

Genistein modulates the expression of Smad2/3 and Smad7. The mechanism of action is through Smad/TGF-β signaling. Genistein significantly ameliorates the fibrotic effects of D-GalN.