Cross-Family Transcription Factor Interactions: An Additional Layer of Gene Regulation

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• 作者：Marian Bemer¹ ; ² ; Aalt D.J. van Dijk³ ; Richard G.H. Immink¹ ; ² ; Gerco C. Angenent¹ ; ² ; ^{Gerco.Angenent@wur.nl}
• 关键词：transcription factor ; protein interactions ; transcription regulation ; DNA binding ; TF families
• 刊名：Trends in Plant Science
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：22
• 期：1
• 页码：66-80
• 全文大小：2717 K
• 卷排序：22

文摘

Specific and dynamic gene expression strongly depends on transcription factor (TF) activity and most plant TFs function in a combinatorial fashion. They can bind to DNA and control the expression of the corresponding gene in an additive fashion or cooperate by physical interactions, forming larger protein complexes. The importance of protein–protein interactions between members of a particular plant TF family has long been recognised; however, a significant number of interfamily TF interactions has recently been reported. The biological implications and the molecular mechanisms involved in cross-family interactions have now started to be elucidated and the examples illustrate potential roles in the bridging of biological processes. Hence, cross-family TF interactions expand the molecular toolbox for plants with additional mechanisms to control and fine-tune robust gene expression patterns and to adapt to their continuously changing environment.