Abnormal vascular and neural retinal morphology in congenital lifetime isolated growth hormone deficiency

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• 作者：Virginia M. Pereira-Gurgel^a ; Augusto C.N. Faro^b ; Roberto Salvatori^c ; ^{salvator@jhmi.edu} ; Thiago A. Chagas^b ; José ; F. Carvalho-Junior^b ; Carla R.P. Oliveira^a ; Ursula M.M. Costa^a ; Gustavo B. Melo^d ; Ann Hellströ ; m^e ; Manuel H. Aguiar-Oliveira^a
• 关键词：Isolated GH deficiency ; GH ; IGF-I ; Retina
• 刊名：Growth Hormone & IGF Research
• 出版年：2016
• 出版时间：October-December 2016
• 年：2016
• 卷：30-31
• 期：Complete
• 页码：11-15
• 全文大小：493 K
• 卷排序：30

文摘

The role of GH/IGFs axis in the human retina is still not clear. Isolated GH deficiency (IGHD) due to a GHRHR mutation can help study this role. Adults with untreated IGHD present a moderate reduction of vascular branching points. IGHD subjects exhibit increase of optic disc and cup, and normal thickness of the macula. Distinct, but benign retinal phenotype is present in congenital IGHD.