Organolithium mediated synthesis of prenylchalcones as potential inhibitors of chemoresistance

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• 作者：Daskiewicz ; Jean B. ; Comte ; Gilles ; Barron ; Denis ; Di Pietro ; Attilio ; Thomasson ; Franç ; ois
• 关键词：aldol reaction ; biologically active compounds ; chalcones ; protecting groups
• 刊名：Tetrahedron Letters
• 出版年：1999
• 出版时间：September 24, 1999
• 年：1999
• 卷：40
• 期：39
• 页码：7095-7098
• 全文大小：207 K

文摘

A number of substituted chalcones have been prepared by a novel LiHMDS-mediated aldol condensation, the first method consistent with the use of alkali-labile protecting groups such as tert-butyldiphenylsilyl or tert-butyldimethylsilyl. Chalcone substitution by prenylation increases their binding affinity to P-glycoprotein responsible for cancer cells chemoresistance.