A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

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A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

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作者：Vijayendran Chandran¹ ; Giovanni Coppola¹ ; ⁸ ; Homaira Nawabi² ; Takao Omura² ; Revital Versano¹ ; Eric A. Huebner² ; Alice Zhang³ ; Michael Costigan² ; Ajay Yekkirala² ; Lee Barrett² ; Armin Blesch⁴ ; ⁹ ; Izhak Michaelevski⁵ ; ¹⁰ ; Jeremy Davis-Turak¹ ; ¹¹ ; Fuying Gao⁸ ; Peter Langfelder⁶ ; ⁷ ; Steve Horvath⁶ ; ⁷ ; Zhigang He² ; Larry Benowitz² ; Mike Fainzilber⁵ ; Mark Tuszynski⁴ ; Clifford J. Woolf² ; Daniel H. Geschwind¹ ; ⁶ ; ^{dhg@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Neuron
出版年：2016
出版时间：2 March 2016
年：2016
卷：89
期：5
页码：956-970
全文大小：6894 K

文摘

•: We identify a transcriptional program observed after PNS, but not CNS injury
•: This program links known signaling pathways via a core set of transcription factors
•: We experimentally and bio-informatically validate several network predictions
•: We use the core transcriptional profile to identify a drug that promotes regeneration

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