First total synthesis of prasinic acid and its anticancer activity

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• 作者：Narayan Chakor ; Ganesh Patil ; Diana Writer ; Giridharan Periyasamy ; Rajiv Sharma ; Abhijit Roychowdhury ; Prabhu Dutt Mishra
• 关键词：Natural Products ; Prasinic Acid ; Anticancer ; Total synthesis
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：1 November, 2012
• 年：2012
• 卷：22
• 期：21
• 页码：6608-6610
• 全文大小：311 K

文摘

The first total synthesis of prasinic acid is being reported along with its biological evaluation. The ten step synthesis involved readily available and cheap starting materials and can easily be transposed to large scale manufacturing. The crucial steps of the synthesis included the formation of two different aromatic units (7 and 9) and their coupling reaction. The synthetic prasinic acid exhibited moderate antitumor activity (IC₅₀ 4.3-9.1 ¦ÌM) in different lines of cancer cells.