An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold

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• 作者：Srinivasulu Cherukupalli ; Rajshekhar Karpoormath ; ^{karpoormath@ukzn.ac.za} ; Balakumar Chandrasekaran ; Girish. A. Hampannavar ; Neeta Thapliyal ; Venkata Narayana Palakollu
• 关键词：Pyrazolo[1 ; 5-a]pyrimidine ; Anti-cancer agents ; Anti-infectious agents ; CNS agents ; Anti-inflammatory agents ; Radiopharmaceuticals
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：298-352
• 全文大小：9444 K
• 卷排序：126

文摘

Pyrazolo[1,5-a]pyrimidine is an important and versatile scaffold in drug design and discovery. Various synthetic approaches for the preparation of pyrazolo[1,5-a]pyrimidine derivatives are summarized. This review describes the chemical structures of the most active pyrazolo[1,5-a]pyrimidine derivatives. Review focuses on structure activity relationship (SAR) studies of pyrazolo[1,5-a]pyrimidine scaffold. The review shall contribute for planning research on pyrazolo[1,5-a]pyrimidines.