The CeCl₃·7H₂O–NaI system as promoter in the synthesis of functionalized trisubstituted alkenes via Knoevenagel condensation

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• 作者：Giuseppe Bartoli ; Romina Beleggia ; Sandra Giuli ; Arianna Giuliani ; Enrico Marcantoni ; Massimo Massaccesi and Melissa Paoletti
• 刊名：Tetrahedron Letters
• 出版年：2006
• 出版时间：11 September 2006
• 年：2006
• 卷：47
• 期：37
• 页码：6501-6504
• 全文大小：113 K

文摘

The arylidene malonates with two different geminal carboxylate functions, a suitable class of substrates of several synthetic and pharmacological studies, are easily available through Knoevenagel condensation of ethyl tert-butyl malonate and different aromatic aldehydes. The results have increased the potentialities of CeCl₃·7H₂O–NaI system as a type of water-tolerant green Lewis acid promoter for carbon–carbon bond forming procedures.