CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene

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• 作者：Shusaku Uchida¹ ; ² ; ³ ; ^{s-uchida@yamaguchi-u.ac.jp} ; Brett J.W. Teubner⁴ ; Charles Hevi³ ; Kumiko Hara¹ ; Ayumi Kobayashi¹ ; Rutu M. Dave³ ; Tatsushi Shintaku¹ ; Pattaporn Jaikhan⁵ ; Hirotaka Yamagata¹ ; ² ; Takayoshi Suzuki² ; ⁵ ; Yoshifumi Watanabe¹ ; Stanislav S. Zakharenko⁴ ; Gleb P. Shumyatsky³ ; ⁶ ; ^{gleb@biology.rutgers.edu}
• 关键词：memory enhancement ; long-term potentiation ; hippocampus ; nuclear transport ; epigenetics ; FGF1 ; CRTC1 ; KAT5/Tip60 ; HDAC3 ; CREB
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：18
• 期：2
• 页码：352-366
• 全文大小：6311 K
• 卷排序：18

文摘

Neuronal stimulation and learning induce Fgf1b in the mouse hippocampus FGF1 is essential for enduring long-term potentiation and memory enhancement Learning-induced nuclear transport of CRTC1 activates Fgf1b transcription CRTC1-mediated substitution of KAT5 for CBP on the Fgf1b promoter enhances memory