Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias

详细信息查看全文

作者：A.L. Colí ; n-Gonzá ; lez^a ; ^&dagger ; ; A.L. Paz-Loyola^a ; ^&dagger ; ; I. Serratos^b ; B. Seminotti^c ; ^&dagger ; ; C.A.J. Ribeiro^c ; ^&dagger ; ; G. Leipnitz^c ; D.O. Souza^c ; M. Wajner^c ; ^d ; ^{mwajner@ufrgs.br" class="auth_mail" title="E-mail the corresponding author} ; A. Santamarí ; a^a ; ^{absada@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：GA ; glutaric acid ; GA I ; glutaric acidemia type I ; GDD ; glutaryl-CoA dehydrogenase ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; KA ; kynurenic acid ; KP ; kynurenine pathway ; l-NAME ; l-nitro-l-arginine methyl ester ; MDA ; Malondialdehyde ; MMA ; methylmalonic acid ; MMAcidemia ; methylmalonic acidemia ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyltetrazolium bromide ; NMDA ; N-methyl-d-aspartate ; NMDAr ; NMDA receptors ; NOS ; nitric oxide synthase ; OA ; organic acidemias ; PA ; propionic acid
刊名：Neuroscience
出版年：2015
出版时间：12 November 2015
年：2015
卷：308
期：Complete
页码：64-74
全文大小：1166 K

文摘

•: Subtoxic quinolinate per se produced no toxicity in rat brain synaptosomes.
•: Glutaric acid and related metabolites were no toxic per se.
•: Toxicity was produced by quinolinate + organic acids.
•: Toxicity was related mostly with oxidative stress.
•: Metabolic acidemias might involve toxic synergism.