The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome

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• 作者：Lady Katerine Serrano Mujica^a ; Kalyne Bertolin^a ; Alessandra Bridi^a ; Werner Giehl Glanzner^a ; Vitor Braga Rissi^a ; Flá ; via de los Santos de Camargo^a ; Renato Zanella^c ; Osmar Damian Prestes^c ; Rafael Noal Moresco^d ; Alfredo Quites Antoniazzi^a ; Paulo Bayard Dias Gonç ; alves^a ; Melissa Orlandin Premaor^b ; Fabio Vasconcellos Comim^a ; ^b ; ^{fcomim@ufsm.br}
• 关键词：Polycystic ovary syndrome ; Developmental programming ; Leuprolide acetate
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：442
• 期：Complete
• 页码：125-133
• 全文大小：1661 K
• 卷排序：442

文摘

GnRH agonist prevented the development of features in a postnatal PCOS rat model. No significant changes with GnRH agonist were noted in prenatal androgenized rats. Disruption in Gnrhr was observed in the ovary and hypothalamus after T treatment.