Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

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Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

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作者：Charlotte Bouckaert^a ; Silvia Serra^a ; Gré ; goire Rondelet^b ; Eduard Dolu&scaron ; ić^c ; Johan Wouters^b ; Jean-Michel Dogné ; ^a ; Raphaë ; l Fré ; dé ; rick^d ; Lionel Pochet^a ; ^{lionel.pochet@unamur.be" class="auth_mail" title="E-mail the corresponding author}
关键词：Coumarins ; Factor XIIa ; Factor XII ; FXII ; Antithrombotic agents ; Benzopyrans
刊名：European Journal of Medicinal Chemistry
出版年：2016
出版时间：3 March 2016
年：2016
卷：110
期：Complete
页码：181-194
全文大小：2670 K

文摘

•: 3-carboxamide coumarins were previously described as selective FXIIa inhibitors.
•: New 3-carboxamide coumarins were synthesized and assessed.
•: An original FXIIa hybrid model was built to carry out a molecular modeling study.
•: This study helped to better understand the activity and selectivity on FXIIa.

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