Effect of microwave heating in the asymmetric addition of dimethylzinc to aldehydes

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• 作者：Miroslav Genov ; Gorka Salas ; Pablo Espinet
• 关键词：Addition reactions ; Asymmetric synthesis ; Aminoalcohols ; Microwave ; Zinc
• 刊名：Journal of Organometallic Chemistry
• 出版年：2008
• 出版时间：15 May 2008
• 年：2008
• 卷：693
• 期：11
• 页码：2017-2020
• 全文大小：183 K

文摘

Microwave-heated enantioselective additions of dimethylzinc to various aldehydes are reported. Dramatically reduced reaction times and lower catalyst loadings (5 % ), compared with conventionally used conditions, can be achieved, with excellent yields and just small loss of enantioselectivity (up to 83 % enantioselectivity is achieved). In the reaction with aliphatic aldehydes the same enantioselectivity has been achieved for microwave-heated and conventional room temperature conditions.