The small GTPase, Rab27, and its effectors and regulators participate in granule exocytosis by parotid acinar cells

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• 作者：Akane Imai^a ; ^b ; ^{imaiak@ngt.ndu.ac.jp} ; Maiko Tsujimura^c ; ^d
• 关键词：Slp ; synaptotagmin-like protein ; Slac2 ; Slp homolog lacking C2 domains ; SHD ; synaptotagmin-like protein homology domain ; GST ; glutathione S-transferase ; IPR ; isoproterenol ; SLO ; streptolysin O ; GAP ; GTPase activating protein ; GEF ; guanine nucleotide exchange factor ; GDI ; GDP dissociation inhibitor ; EPI64 ; EBP50-PDZ interactor of 64  ; kDa ; TBC ; Tre-2/Bub2/Cdc16 ; MADD ; MAP-kinase activating death domain protein ; DENN ; differentially expressed normal versus neoplastic ; DENND ; DENN/MADD domain co
• 刊名：Journal of Oral Biosciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：59
• 期：1
• 页码：12-16
• 全文大小：571 K
• 卷排序：59

文摘

Rab proteins are small GTPases that are essential components involved in the control of eukaryotic intracellular membrane trafficking. Previously, we investigated whether Rab proteins are involved in the exocytosis of amylase-containing granules in rat parotid acinar cells.HighlightRab27 and its effectors regulate amylase release from parotid acinar cells.ConclusionExocytosis occurs via a Rab27 GDP/GTP cycling mechanism in parotid acinar cells.