Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Opening Hours
Collections
Help Via Email

Electronic Information Resources

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

详细信息查看全文

作者：Christine Altmann^a ; Stefanie Hardt^a ; Caroline Fischer^a ; Juliana Heidler^c ; Hee-Young Lim^a ; Annett Hä ; ussler^a ; Boris Albuquerque^a ; B&eacute ; la Zimmer^a ; Christine Mö ; ser^a ; Christian Behrends^b ; Frank Koentgen^d ; Ilka Wittig^c ; Mirko H.H. Schmidt^e ; Albrecht M. Clement^f ; Thomas Deller^g ; Irmgard Tegeder^a ; ^{tegeder@em.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author}
关键词：Pain ; Nerve injury ; Sensory neuron ; Autophagy ; Progranulin ; Dorsal root ganglia
刊名：Neurobiology of Disease
出版年：2016
出版时间：December 2016
年：2016
卷：96
期：Complete
页码：294-311
全文大小：4421 K

文摘

el">•: Progranulin overexpression in nociceptive neurons resolves neuropathic pain after nerve injury.
el">•: Progranulin reduces protein aggregates in injured neurons.
el">•: Hydroxychloroquine, which blocks autophagic flux intensifies nociception.
el">•: Progranulin interacts with autophagy proteins, promotes autophagy and neuronal survival.
el">•: Proteomics show progranulin-dependent regulations of proteins involved in autophagy, lysosome and endocytosis.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.