Mixed T Cell Chimerism After Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Using an Alemtuzumab-Containing Regimen Is Shaped by Persistence of Recipient CD8 T Cells

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• 作者：Francesco Grimaldi¹ ; ² ; Victoria Potter¹ ; Pilar Perez-Abellan³ ; John P. Veluchamy³ ; Muhammad Atif³ ; Rosemary Grain³ ; Monica Sen³ ; Steven Best¹ ; Nicholas Lea¹ ; Carmel Rice¹ ; Antonio Pagliuca¹ ; Ghulam J. Mufti¹ ; ³ ; Judith C.W. Marsh¹ ; ³ ; ^{judith.marsh@nhs.net} ; Linda D. Barber³ ; ^{linda.barber@kcl.ac.uk}
• 关键词：Hematopoietic stem cell transplantation ; Alemtuzumab ; Aplastic anemia ; T cells ; Chimerism
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：293-299
• 全文大小：1012 K
• 卷排序：23

文摘

Clinical outcomes are excellent using an alemtuzumab-containing hematopoietic stem cell transplantation regimen for aplastic anemia. Outcomes are excellent despite prolonged abnormality of the T cell profile. Recipient-derived CD8 T cells shape persistent mixed chimerism.