Model-observational bridging study on the effectiveness of ezetimibe on cardiovascular morbidity and mortality in France: A population-based study

详细信息    查看全文

• 作者：Jean Ferriè ; res ; MD ; MSc ; FESC^a ; Jean Dallongeville ; MD ; PhD^b ; Michel Rossignol ; MD ; MSc ; FRCPC^c ; ^d ; Jacques Bé ; nichou ; MD ; PhD^d ; ^e ; J. Jaime Caro ; MDCM ; FRCPC ; FACP^c ; ^f ; Denis Getsios ; BA^f ; Luis Hernandez ; MSc^f ; Lucien Abenhaim ; MD ; PhD^d ; ^g ; Lamiae Grimaldi-Bensouda ; PharmD ; PhD^d ; ^h ; ^{lamiae.grimaldi@la-ser.com}
• 关键词：Cardiovascular disease ; Cohort ; Lipid-modifying drugs ; Prevention ; Hypercholesterolemia
• 刊名：Journal of Clinical Lipidology
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：10
• 期：6
• 页码：1379-1388
• 全文大小：326 K
• 卷排序：10

文摘

Non-interventional 48-month follow-up cohort in 3215 hypercholesterolemic patients. NNT to prevent 1 non-fatal or fatal CV event was 143 patients treated for 5 years. Exposure to ezetimibe plus statin provided the largest effect in LDL-C reduction. The MOBS methodology was shown to be effective at predicting CV event rates.