Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation

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• 作者：Lei Li¹ ; ⁷ ; Yu Cao¹ ; ⁷ ; Haitao Wu¹ ; Xinchun Ye¹ ; Zhihui Zhu¹ ; Guanglin Xing¹ ; Chengyong Shen¹ ; Arnab Barik¹ ; Bin Zhang¹ ; Xiaoling Xie⁴ ; Wenbo Zhi⁵ ; Lin Gan⁴ ; Huabo Su⁶ ; Wen-Cheng Xiong¹ ; ² ; ³ ; Lin Mei¹ ; ² ; ³ ; ⁸ ; ^{lmei@augusta.edu}
• 关键词：rapsyn ; AChR ; RING domain ; neddylation ; E3 ligase
• 刊名：Neuron
• 出版年：2016
• 出版时间：7 December 2016
• 年：2016
• 卷：92
• 期：5
• 页码：1007-1019
• 全文大小：3581 K
• 卷排序：92

文摘

RING domain of rapsyn contains E3 ligase activity Rapsyn E3 ligase activity catalyzes neddylation as well as ubiquitination Agrin promotes AChR neddylation for cluster formation Rapsyn E3 ligase activity is required for AChR clustering and NMJ assembly