Depression is a systems disorder including mood, behavioral, and peripheral somatic disturbances.

Ceramide is a crucial constituent of biological membranes and signaling lipid in all cells.

Brain ceramide controls hippocampal neurogenesis and depression-like behavior in animal models.

The acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs.

Ceramide links brain dysfunction and somatic disturbances in major depressive disorder.