Disruption of the blood-brain barrier in pigs naturally infected with Taenia solium, untreated and after anthelmintic treatment

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• 作者：Cristina Guerra-Giraldez ; Miguel Marzal ; Carla Cangalaya ; Diana Balboa ; Miguel ¨¢ngel Orrego ; Adriana Paredes ; Eloy Gonzales-Gustavson ; Gianfranco Arroyo ; Hector H. Garc¨ªa ; Arm ; o E. Gonz¨¢lez ; Siddhartha Mahanty ; Theodore E. Nash ; The cysticercosis working group in Peru
• 关键词：Blood&ndash ; brain barrier ; Neurocysticercosis ; Taenia solium ; Praziquantel
• 刊名：Experimental Parasitology
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：134
• 期：4
• 页码：443-446
• 全文大小：473 K

文摘

Neurocysticercosis is a widely prevalent disease in the tropics that causes seizures and a variety into of neurological symptoms in most of the world. Experimental models are limited and do not allow assessment of the degree of inflammation around brain cysts. The vital dye Evans Blue (EB) was injected to 11 pigs naturally infected with Taenia solium cysts to visually identify the extent of disruption of the blood-brain barrier. A total of 369 cysts were recovered from the 11 brains and classified according to the staining of their capsules as blue or unstained. The proportion of cysts with blue capsules was significantly higher in brains from pigs that had received anthelmintic treatment 48 and 120 h before the EB infusion, indicating a greater compromise of the blood-brain barrier due to treatment. The model could be useful for understanding the pathology of treatment-induced inflammation in neurocysticercosis.