Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways

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• 作者：Sun Woo Jin^a ; ¹ ; Yong Pil Hwang^b ; ¹ ; Chul Yung Choi^c ; Hyung Gyun Kim^a ; Se Jong Kim^a ; Yongan Kim^a ; Young Chul Chung^d ; Kyung Jin Lee^e ; Tae Cheon Jeong^f ; Hye Gwang Jeong^a ; ^{hgjeong@cnu.ac.kr}
• 关键词：Rutaecarpine ; Oxidative stress ; HO-1 ; Nrf2 ; CaMKII ; Akt
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：100
• 期：Complete
• 页码：138-148
• 全文大小：2240 K
• 卷排序：100

文摘

Rutaecarpine protects human hepatocytes against t-BHP-induced cell death. Rutaecarpine enhanced HO-1, NQO-1, and GCL expression. Antioxidative enzyme expression was upregulated by activation of Nrf2 and CaMKII/Akt.