The comparative in vitro assessment of e-cigarette and cigarette smoke aerosols using the γH2AX assay and applied dose measurements

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• 作者：David Thorne ; ^{David_Thorne@bat.com} ; Sophie Larard ; Andrew Baxter ; Clive Meredith ; Marianna Gaҫa
• 关键词：ACM ; aerosol collected mass ; ALI ; air liquid interface ; ATCC ; American type culture collection ; BEAS-2Bs ; human bronchial epithelial cells ; BEGM ; bronchial epithelial cell growth medium ; CRM No 81 ; CORESTA Recommended Method No 81 ; E-cigarettes ; electronic cigarettes ; GC ; gas chromatography ; HCI ; health Canada intense puffing regimen ; HPLC ; high performance liquid chromatography ; ISO ; International Organisation of Standardisation ; PG ; propylene glycol ; QCM ; quartz crystal microbalance ; RCC ; rela
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：170-178
• 全文大小：853 K
• 卷排序：265

文摘

Cigarette smoke generates a dose dependent increase in double strand breaks. E-cigarette aerosols did not generate any increases in double strand breaks above control levels. E-cigarette exposures were approximately 28-fold greater than that of cigarette smoke exposures. In vitro dosimetry ensures accurate interpretation of the data, and confirms delivery of test agent. In vitro dosimetry allows cross-product, study and system comparisons.