Dried haematic microsamples and LC-MS/MS for the analysis of natural and synthetic cannabinoids

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• 作者：Michele Protti^a ; James Rudge^b ; Angelo Eliseo Sberna^c ; Gilberto Gerra^d ; Laura Mercolini^a ; ^{laura.mercolini@unibo.it}
• 关键词：Volumetric absorptive microsampling (VAMS) ; Dried blood spot (DBS) ; Natural cannabinoids ; Synthetic cannabinoids ; LC&ndash ; MS/MS
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1044-1045
• 期：Complete
• 页码：77-86
• 全文大小：1144 K
• 卷排序：1044

文摘

First study on quantitative bioanalysis of natural and synthetic cannabinoids by DBS/VAMS-LC–MS/MS. Performance comparison between DBS and VAMS strategies. Data adherence between capillary and venous DBS/VAMS and between dried samples and plasma analysis. Haematocrit issues carefully studied and effectively addressed. Advances and improvements in the monitoring of new psychoactive compounds.