Coxsackievirus B3 induces the formation of autophagosomes in cardiac fibroblasts both in vitro and in vivo

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Coxsackievirus B3 induces the formation of autophagosomes in cardiac fibroblasts both in vitro and in vivo

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作者：Xia Zhai^a ; ^{zhai_xia_cool@126.com" class="auth_mail" title="E-mail the corresponding author} ; Ying Qin^a ; ^{qinyinggaofeng@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yang Chen^a ; ^{cy_hmu@126.com" class="auth_mail" title="E-mail the corresponding author} ; Lexun Lin^a ; ^{linlexun@163.com" class="auth_mail" title="E-mail the corresponding author} ; Tianying Wang^a ; ^{wangty0929@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaoyan Zhong^a ; ^{littlerock712@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiaoyu Wu^c ; ^{xiaoyu_wu2006@163.com" class="auth_mail" title="E-mail the corresponding author} ; Sijia Chen^a ; ^{chensj0802@163.com" class="auth_mail" title="E-mail the corresponding author} ; Jing Li^d ; ^{jing070822@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yan Wang^a ; ^{wangyan@hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Fengmin Zhang^a ; ^{fengminzhang@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Wenran Zhao^b ; ^{zhaowenran2002@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; ^{zhaowr@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhaohua Zhong^a ; ^{zhongzh@hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：CVB ; coxsackievirus B ; IL ; interleukin ; TNF ; tumor necrosis factor ; IFN ; interferon ; ORF ; open reading frame ; MOI ; multiplicity of infection ; EGFP ; enhanced green fluorescence protein ; LC3 ; microtubule-associated protein 1light chain 3 ; PCR ; polymerase chain reaction ; 3-MA ; 3-methyladenine ; ERK ; extracellular regulated kinase ; MAVS ; mitochondrial antiviral signaling protein ; TRIF ; Toll/IL-1 receptor domain-containing adaptor inducing interferon-beta
刊名：Experimental Cell Research
出版年：2016
出版时间：10 December 2016
年：2016
卷：349
期：2
页码：255-263
全文大小：1687 K

文摘

•: CVB3 replication induced autophagosome assembly in primary cardiac fibroblasts.
•: Both IL-6 and TNF-α in cardiac fibroblasts infected by CVB3 were increased.
•: IL-6 and TNF-α were reduced in cardiac fibroblasts when autophagy was inhibited.
•: Autophagosome assembly in cardiac fibroblasts of CVB-infected mice was increased.