Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

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• 作者：Hong Han¹ ; ² ; ⁶ ; Ulrich Braunschweig¹ ; ⁶ ; Thomas Gonatopoulos-Pournatzis¹ ; Robert J. Weatheritt¹ ; ³ ; Calley L. Hirsch⁴ ; Kevin C.H. Ha¹ ; ² ; Ernest Radovani¹ ; ² ; Syed Nabeel-Shah¹ ; ² ; Tim Sterne-Weiler¹ ; Juli Wang¹ ; Dave O&rsquo ; Hanlon¹ ; Qun Pan¹ ; Debashish Ray¹ ; Hong Zheng¹ ; Frederick Vizeacoumar⁴ ; Alessandro Datti⁴ ; Lilia Magomedova⁵ ; Carolyn L. Cummins⁵ ; Timothy R. Hughes¹ ; ² ; Jack F. Greenblatt¹ ; ² ; Jeffrey L. Wrana² ; ⁴ ; Jason Moffat¹ ; ² ; Benjamin J. Blencowe¹ ; ² ; ⁷ ; ^{b.blencowe@utoronto.ca}
• 关键词：alternative splicing ; splicing factors ; transcription factors ; spliceosome ; chromatin ; RNA interference ; embryonic stem cells ; neuroblastoma cells ; SPAR-seq ; high-throughput screening
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：65
• 期：3
• 页码：539-553.e7
• 全文大小：3127 K
• 卷排序：65

文摘

SPAR-seq is a versatile method for elucidating endogenous RNA regulatory networks Hundreds of trans-acting factors control ES and neural splicing networks SPAR-seq defines positive and negative functional and physical interrelationships Transcription factors have dual direct and indirect roles in splicing regulation