Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group

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• 作者：Haoran Liu^a ; Linbo Liu^a ; Xiaohui Gao^b ; Yingzi Liu^c ; ^{liuyingzi111@sina.com} ; Wanjun Xu^c ; Wei He^c ; Hong Jiang^c ; Jingjing Tang^a ; Haoqun Fan^a ; Xinhua Xia^b
• 关键词：Alzheimer's disease ; Ferulic acid ; Acetylcholinesterases ; Molecular docking ; α ; β-Unsaturated carbonyl
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：810-822
• 全文大小：852 K
• 卷排序：126

文摘

Many novel ferulic acid amide derivatives with tertiary amine group revealed inhibitory effects against AChE and BuChE. Carbon chain length and tertiary amine side chain markedly influenced the inhibition activity against AChE. If benzamide group was removed or replaced by ethyl ester group, the activity in inhibiting AChE decreased significantly.