Lipid-coated hollow mesoporous silica nanospheres for co-delivery of doxorubicin and paclitaxel: Preparation, sustained release, cellular uptake and pharmacokinetics

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• 作者：Yang Qiu ; Chao Wu ; ^{wuchao27@126.com} ; Jie Jiang ; Yanna Hao ; Ying Zhao ; Jie Xu ; Tong Yu ; Peng Ji
• 关键词：Lipid-coated hollow mesoporous silica nanospheres ; Paclitaxel ; Doxorubicin ; Drug combination ; Synergistic effect
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：835-843
• 全文大小：1500 K
• 卷排序：71

文摘

L-HMSN as a platform is used for combination of DOX and PTX The drug delivery system demonstrates synergy effect in inhibiting A549 cell proliferation The drug delivery system slowly releases the drugs and improves drug absorption