Significance of CD66c expression in childhood acute lymphoblastic leukemia

详细信息    查看全文

• 作者：Nobutaka Kiyokawa ; Kazutoshi Iijima ; Osamu Tomita ; Masashi Miharu ; Daisuke Hasegawa ; Kenichiro Kobayashi ; Hajime Okita ; Michiko Kajiwara ; Hiroyuki Shimada ; Takeshi Inukai ; Atsushi Makimoto ; Takashi Fukushima ; Toru Nanmoku ; Katsuyoshi Koh ; Atsushi Manabe ; Akira Kikuchi ; Kanji Sugita ; Junichiro Fujimoto ; Yasuhide Hayashi ; Akira Ohara ; et al.
• 关键词：CD66c ; Acute lymphoblastic leukemia ; CRLF2 ; Flow cytometry ; Genetic abnormality
• 刊名：Leukemia Research
• 出版年：January, 2014
• 年：2014
• 卷：38
• 期：1
• 页码：42-48
• 全文大小：1392 K

文摘

Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.