Measurement of cerebral blood flow with dynamic susceptibility contrast MRI and comparison with O-15 positron emission tomography

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• 作者：Enmi ; Jun-ichiro ; Hayashi ; Takuya ; Watabe ; Hiroshi ; Moriwaki ; Hiroshi ; Yamada ; Naoaki ; Iida ; Hidehiro
• 关键词：Dynamic susceptibility contrast MRI ; ¹⁵O Positron emission tomography ; Cerebral blood flow ; Cerebral blood volume
• 刊名：International Congress Series
• 出版年：2004
• 出版时间：August, 2004
• 年：2004
• 卷：1265
• 期：Complete
• 页码：150-158
• 全文大小：183 K

文摘

Cerebral blood flow (CBF) obtained by dynamic susceptibility contrast MRI (DSC-MRI) often provides an abnormal contrast between normal and ischemic areas, as compared with those from positron emission tomography (PET) or SPECT. A linear relationship is normally assumed in the transverse relaxation rate change in relation to the regional concentration of the contrast agent. This study was intended to evaluate this assumption. The impact of an alternative, non-linear model based on a realistic capillary structure was also evaluated in the assessment of CBV and CBF by use of DSC-MRI. DSC-MRI and ¹⁵O-PET were carried out on 13 patients with chronic cerebrovascular disease. Regions-of-interest (ROI) were selected both in the ischemic and unaffected hemispheres, and the left-to-right (L/R) ratios of CBF and CBV were compared between PET and DSC-MRI. When assuming the linear relationship, the contrast of CBF by DSC-MRI was lower than that by PET (CBF_L/R,MRI